２０１３

２０１３年
１．原著論文
1.     Kazuki Shimane, KumiKawaji, Fusako Miyamoto, Shinya Oishi, Kentaro Watanabe,YasukoSakagami, Nobutaka Fujii, Kazuya Shimura, Masao Matsuoka, Mitsuo Kaku, StefanSarafianos, and Eiichi Kodama. HIV-1 resistance mechanism to an electrostatically constrainedpeptide fusion inhibitor that is active against T-20-resistant strains.Antimicrobal Agents andChemotherapy  57:4035-4038, 2013


2.       Kazuki Izumi, Kumi Kawaji, Fusasko Miyamoto, Kazuki Shimane, Kazuya Shimura, YasukoSakagami, Toshio Hattori, Kentaro Watanabe, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka,Mitsuo Kaku, Stefan G. Sarafianos, and Eiichi N. Kodama.  Mechanism of Resistance to S138ASubstituted Enfuvirtide and its Application to Peptide Design.International Journal ofBiochemistry and Cell Biology 45:908-915, 2013.


3.     Eleftherios Michailidis, EmilyM Ryan, Atsuko Hachiya, KarenA Kirby, Bruno Marchand,MaxwellD Leslie, AndrewD Huber, et al. Hypersusceptibility Mechanism of Tenofovir-Resistant HIVto EFdA.Retrovirology10:65doi:10.1186/1742-4690-10-65, 2013

4.    Atsuko Hachiya, Aaron Reeve, Bruno Marchand, Eleftherios Michailidis, Yee Ong, Karen Kirby,Maxwell Leslie, Shinichi Oka, Eiichi Kodama, Lisa Rohan, Hiroaki Mitsuya, Michael Parniak, andStefan Sarafianos. Evaluation of combinations of 4'-ethynyl-2-fluoro-2'-deoxyadenosine withclinically used antiretroviral drugs.Antimicrobal Agents and Chemotherapy57:4554-4558, 2013.

5.     Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, HagedornAN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA, Sarafianos SG.Effects ofsubstitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.Antimicrobal Agents and Chemotherapy57:6254-64, 2013.


２．総説
1.     Fusako Miyamoto and Eiichi N Kodama. Development of small molecule HIV-1 fusioninhibitors: linking Biology to Chemistry.Current Pharmaceutical Design19:1827-34, 2013

2.     児玉栄一、宮本総子　新しい抗ウイルス剤開発の考え方　臨床と微生物　40:51-55, 2013      

     
３．学会発表
1.     Fusako Miyamoto, Fumiko Tomiyama, Kumi Kawaji, Mitsuo Kaku, Eiichi Kodama. Profile of anovel HIV reverse　transcriptase inhibitor. NIH Tohoku University JSPS Symposium, Sendai, Japan,May 9-11, 2013

2.     児玉栄一. MAGI細胞による薬剤screeningにおいて酵素法がヒット化合物検出に優れる. 第27回日本エイズ学会学術集会. 熊本, Nov. 20-22, 2013.



Current Pharmaceutical Designから引用

HIV gp41を介した細胞融合機構の模式図とその阻害剤T-20などの作用機序。

我々はT-20と比べて１００倍近く効果が強いSC34EKを開発し、その活性を失わずに

ペプチドサイズを29まで小さくすることに京都大学大学院薬学研究科藤井教授、大石講師とともに成功させた。