２０２５

２０２５年
1. 原著論文

1.　Hironori Hayashi, Kazuya Hasegawa, Erika Saijo, Eiich N. Kodama, Kazutaka Murayama
Binding of a potential antibacterial drug, mangiferin, to serine hydroxymethyltransferase fromEnterococcus faecium.
Biochemical and Biophysical Research Communications　743:151177, 2025. doi: 10.1016/j.bbrc.2024.151177.

２．Aoi Takahara, Toru Nakatsu, Kazushige Hirata, Hironori Hayashi, Kumi Kawaji, Keisuke Aoki,Shinsuke Inuki, Hiroaki Ohno, Hiroaki Kato, Eiichi Kodama, and Shinya Oishi.
Elucidation of Postfusion Structures of Measles Virus F Protein for the Structure-Based Design ofFusion Inhibitors.
Journal of Medicinal Chemistry　68(3):3123-3133, 2025.  doi: 10.1021/acs.jmedchem.4c02337

3.   Haruka Imai, Jun Suzuki, Tomoki Mizuno, Shota Takahashi, Hideya Itagaki, Makiko Yoshida,Shiro Endo, Eiichi N. Kodama. The effect of antibiotic prescription in non-critically ill hospitalizedpatients with COVID-19: A Japanese inpatient database study.
PLoS One　20(3):e0318803, 2025.  doi:10.1371/journal.pone.0318803

4.   Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya,Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, YukaKotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui,Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara,Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa.  
Has the impact of cigarette smoking on mortality been underestimated by overlooking secondhandsmoke? Tohoku Medical Megabank Community-based Cohort Study.
BMJ Public Health　3(1):e001746　 doi: 10.1136/bmjph-2024-001746

５．Masato Takase Naoki Nakaya Tomohiro Nakamura Mana Kogure Rieko Hatanaka Kumi NakayaIppei Chiba Sayuri Tokioka Ikumi Kanno Kotaro Nochioka Naho Tsuchiya Takumi Hirata Akira NaritaTaku Obara Mami Ishikuro Hisashi Ohseto Akira Uruno Tomoko Kobayashi Eiichi N Kodama YoheiHamanaka Masatsugu Orui Soichi Ogishima Satoshi Nagaie Nobuo Fuse Junichi Sugawara ShinichiKuriyama Biobank Japan Project; Koichi Matsuda Yoko Izumi Kengo Kinoshita Gen Tamiya AtsushiHozawa Masayuki Yamamoto.
Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricemia in a General JapanesePopulation: The Tohoku Medical Megabank Community-based Cohort Study.　
Rheumatology　64(5):2591-2600, 2024.　doi:10.1093/rheumatology/keae492

６．Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba,Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, MamiIshikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N.Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, SatoshiYasuda, Atsushi Hozawa.
Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of AtrialFibrillation.
Circulation Journal　89(6):757-764, 2025.   doi: 10.1253/circj.CJ-24-0780

7.    Nobuo Fuse, Hayato Anzawa, Miyuki Sakurai, Ikuko N Motoike, Satoshi Nagaie, TomohiroNakamura, Akiko Miyazawa, Eiichi N Kodama, Masatsugu Orui, Yohei Hamanaka, TomokoKobayashi, Akira Uruno,  Makiko Taira, Ritsuko Shimizu, Naoki Nakaya, Mami Ishikuro, Taku Obara,Fuji Nagami, Soichi Ogishima, PFumiki Katsuoka, Kazuki Kumada, Shinichi Kuriyama, AtsushiHozawa, Yoko Izumi, Kengo Kinoshita, Masayuki Yamamoto　
Genome-wide association study of intraocular pressure in population-based cohorts in Japan: TheToMMo Eye Study.
Ophthalmology Science　5:100821, 2025 https://doi.org/10.1016/j.xops.2025.100821

8.    Takafumi Akimoto, Hiroshi Inaba, Soichi Ogishima, Kazuki Kumada, Ayano Mitsuhashi, RyuiMiyashita, Tomoko Yamaguchi, Masato Bingo, Yushi Chikasawa, Keiko Shinozawa, TakeshiHagiwara, Kagehiro Amano, Eiichi N. Kodama, Ei Kinai.
Comparison of genotypes and phenotypes for von Willebrand factor gene variants using Japanesegenome database.
Blood Vessels, Thrombosis & Hemostasis　2(3):100070, 2025　https://doi.org/10.1016/j.bvth.2025.100070
　　　　その他の業績（プレスリリース１）を論文化しています。

9.    Yue Shi, Taro Ozaki, Yohei Morishita, Tohru Taniguchi, Hiroyasu Sato, Yoshitaka Aoyama,Akihiro Sugawara, Kaho Numata, Tomoya Fuse, Ryo Matsuda, Kento Hosotani, Hanako Fukano,Yoshihiko Hoshino, Aki Hirabayashi, Masato Suzuki, Jiro Yasuda, Rokusuke Yoshikawa, HironoriHayashi, Eiichi N. Kodama, Yoshitaka Shimotai, Hiroshi Hamamoto, Rohan A. Davis, and TeigoAsai.
Genome Mining-Based Discovery of Pyrano[2,3-c]pyrrole Type Natural Products Possessing AlkylSide Chain with Branched Methyl Groups　
Organic Letters　27(31):8580-8585, 2025　doi: 10.1021/acs.orglett.5c02504

10.   Takase Masato, Nakaya Naoki, Kogure Mana, Hatanaka Rieko, Nakaya Kumi, Chiba Ippei,Tokioka Sayuri, Nakamura Nochioka, Nakamura Tomohiro, Hirata Takumi, Koshiba Seizo, KumadaKazuki, Motoike Ikuko, Hishinuma Eiji, Narita Akira, Obara Mami, Ohseto Hisashi, Takahashi Ippei,Kobayashi Tomoko, Kodama Eiichi, Hamanaka Yohei, Orui Masatsugu, Ogishima Soichi, NagaieSatoshi, Fuse Nobuo, Sugawara Junichi, Matsuda Kuriyama Shinichi, Matsuda Yoko Izumi, OhnedaKinuko, Kinoshita Kengo, Hozawa Atsushi, and Yamamoto Masayuki　
Association of circulating metabolites and polygenic risk score with incident diabetes
Cardiovascular Diabetology　24(1):335, 2025.  doi: 10.1186/s12933-025-02849-8.

11.　　Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, ManaKogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, TakuObara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi Kodama, SatoshiNagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda,and Atsushi Hozawa.
Sex difference of genetic risk in the prevalence of atrial fibrillation.Heart  Rhythm　22(9):e631-639, 2025　 https://doi.org/10.1016/j.hrthm.2025.03.1974

12.　　Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, Masatsugu Orui, Genki Shinoda,Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Hiroko Matsubara, Hirohito Metoki, MasahiroKikuya, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Mana Kogure, Naoki Nakaya, JunichiSugawara, Shigeo Kure, Mika Kobayashi, Tomoko Kobayashi, Yoichi Suzuki, Hiroshi Kawame, MikaSakurai-Yageta, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Satoshi Mizuno, SatoshiNagaie, Soichi Ogishima, Akira Narita, Gen Tamiya, Sachie Koreeda, Fuji Nagami, Toru Tamahara,Maki Goto, Akihito Otsuki, Makiko Taira, Takanori Hidaka, Junko Kawashima, Eiichi N. Kodama,Akira Uruno, Yohei Hamanaka, Hiroaki Tomita, Hiroaki Hashizume, Kenichi Noguchi, FumikiKatsuoka, Seizo Koshiba, Kazuki Kumada, Takahiro Nobukuni, Kinuko Ohneda, Shunji Mugikura,Ritsuko Shimizu, Masataka Kambe, Yoshinobu Saito, Tadao Kobayashi, Yoko Izumi, KengoKinoshita, Nobuo Fuse, Nobuo Yaegashi, Atsushi Hozawa, Masayuki Yamamoto, Shinichi Kuriyama.
Cohort Profile Update: the Tohoku Medical Megabank Project Birth and Three-Generation CohortStudy (TMM BirThree Cohort Study) 2023.  
International Journal of Epidemiology　54(5):dyaf148, 2025 DOI10.1093/ije/dyaf148

13.　　Takase Masato, Takumi Hirata, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, KumiNakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya,Hirohito Metoki, Michihiro Satoh, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, IppeiTakahashi, Tomoko Kobayashi, Eiichi Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima,Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa,and Masayuki Yamamoto.　
Associations of family hypertension history, genetic and lifestyle risks with incident hypertension　Hypertension Research　48:2606-2617, 2025　doi: 10.1038/s41440-025-02314-9.

14.　　Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba,Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, IkumiKanno, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Akira Uruno,Tomoko Kobayashi, Eiichi N. Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, SatoshiNagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, KengoKinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto.
Effect of Healthy Lifestyle on Renal Dysfunction Risk: Interactions with Genetic Risk.　
Clinical Kidney Journal　18(10):sfaf275, 2025　doi: 10.1093/ckj/sfaf275

15.　　中鉢奈津子、三木康宏、川内淳史、児玉栄一、伊藤 潔　
医学・人文社会科学の連携で 100 年前のパンデミック"スペイン風邪"を追求　
リサーチ・アドミニストレーション協議会誌　
RMAN-J Journal3:13-15, 2025

2．総説


3．学会発表
1．　児玉 栄一、和田 健彦  　TMPRSS2発現VeroE6細胞を用いた簡便な抗インフルエンザアッセイの確立　第19回 日本ケミカルバイオロジー学会　2025年６月4日-6日　京都大学（京都）
2.     石黒 真美、小原 拓、大類 真嗣、熊田 和貴、工藤 久智、荻島 創一、中谷 直樹、寳澤 篤、栗山 進一、Enejda Senko、Laura H. Hendrix、小河原 修、Anita Iyer、John D. Diaz-Decaro、児玉 栄一　本邦におけるサイトメガロウイルス感染と流産・死産との関連　PO9-4　第61回日本周産期新生児学会　大阪国際会議場　2025年7月13-４日　大阪
３．　児玉栄一、石黒真美、小原拓、大類真嗣、熊田和貴、工藤久智、荻島創一、中谷直樹、寳澤篤、栗山進一、Katja Engelberg、 Enejda Senko、Laura H. Hendrix、小河原 修、John D. Diaz-Decaro.　東北メディカル・メガバンク計画三世代コホート（児童および若年成人） におけるcytomegalovirusおよびEpstein-Barr virus抗体保有率　P-21第29回日本ワクチン学会 第66回日本臨床ウイルス学会 合同学術集会　2025年9月27-8日　札幌コンベンションセンター　札幌
その他の業績

1. プレスリリース
１．　フォン・ヴィレブランド病（VWD）に関連する遺伝子変異があっても出血しやすいとは限らない
　　　　　東京医科大学との共同研究。東北メディカル・メガバンク機構の8.3KJPNのデータから日本人
　　　　　のゲノム解析で見つかったVW因子遺伝子変異の多くは、病的と予測されても実際には症状が出
　　　　　ないことが多く、発症のしやすさや程度には個人差があることが分かりました。

2．招待講演関連
１．　社会医学系専門医制度必修プログラム・感染対策　「人類とパンデミック　賢者は歴史に学ぶ」
　　　第98回 日本産業衛生学会　仙台国際センター　仙台市　2025年5月14日-17日　
２．   感染対策セミナー「感染症トリビア2025」　公立藤田総合病院 　福島県伊達市　7月10日　


2025.11.25:  論文4 報を追加
2025.10.28:  日本ウイルス学会（浜松）に参加
2025. 9.27:  日本ワクチン学会・臨床ウイルス学会（札幌）で発表
2025.  9. 5:  論文4 報と招待講演を追加
2025.  8. 5:  仙台たなばたまつりの花火が研究室からよく見えました
2025.  7.13:  第61回日本周産期新生児学会で発表
2025.  6.15:  論文２報を追加
2025.  6. 7:  白馬シンポジウム（神戸）に参加
2025.  6. 6:  Chemical Biology学会（京都）で発表
2025.  4.25:  論文４報を更新
2025.  4. 7:  研究室に新しいメンバーが加わりました
2025.  2.14:  疫学会（高知）に参加